Earli tackles the #1 problem in the $100B cancer drug market: systemic toxicity. On-target/off-tumor effects force suboptimal dosing, reduced efficacy and sidelining some of the most potent drug classes such as cytokines. Earli’s BioAI approach flips this paradigm: Drugs are produced only where needed— in the tumor, by the tumor, against the tumor.

Cancer cells become their own drug factories, enabling localized immune activation, even in cold tumors. This was enabled by three core innovations: Extrahepatic lipid nanoparticles (LNPs) that reach tumors such as lung cancer AI-designed genetic switches that activate only in malignant cells by sensing transcription factor dysregulation Local production of immune therapies (TCEs, cytokines, multispecifics) at the tumor site — “produce locally, consume locally” Together, these technologies create a new biological control layer, allowing tumors to self-identify and trigger their own targeted immune attack—achieving specificity beyond current targeted or IO therapies. Earli plans to enter the clinic by mid-2027 with a Phase 1/2 lung cancer trial.

The company is backed by a16z, Khosla, Perceptive, Alex Gorsky, Marc Benioff, Breyer, Emerson Collective, Sands Capital and others. The SAB includes Jim Allison (Nobel Laureate, MD Anderson), Bob Langer (Co-founder Moderna, MIT), Phil Greenberg (Co-founder Juno), Amy Abernethy (frm. Principal Deputy FDA Commissioner), Bill Hait (former J&J EVP Oncology R&D), and Alan Ashworth (President UCSF Cancer Center).

The leadership team brings deep gene therapy, LNP, CMC and tech experience; CEO Cyriac Roeding previously led a $250M (11x return) exit.

Who You Are

You share our same sense of dedication, scientific passion and entrepreneurial spirit You work well in a fast-paced and extremely focused startup environment You are not only smart, but clever and constantly think outside the box You are able to make logical decisions in an instant when there is little time to evaluate You are a natural communicator and relationship builder You stay calm under high pressure and stress You have the ability to multi-task in a serious way, with an extreme attention to detail You become a representative of the core DNA of the company through

The Position Earli is currently seeking a Head of Translational Biology to oversee and lead the translational/in vivo biology group. The successful candidate will have a proven track record of successfully initiating and managing pharmacology and translational science projects across oncology indications from Discovery through IND enabling studies. She/he will be responsible for working with the existing scientific leadership for the design and planning of in vivo preclinical studies to characterize the efficacy, PK/PD and safety properties of Earli’s proprietary compounds .

This position will report to the Chief Scientific Officer.

Responsibilities

Oversee and manage the Translational Biology group at Earli to support the growth and expansion of the team Proactively foster the growth of team members and identify opportunities for staff to develop into top-tier, independent pharmacology team members Help lead strategic planning and oversight of internal and external efforts to assess efficacy and safety testing of Earli’s compounds for therapeutic applications across multiple pre-clinical in vivo models.

Requirements

D. in Pharmacology, Pharmaceutical Sciences, Toxicology or related discipline DABT preferred, but not required. D.